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KMID : 1161420200230030335
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Journal of Medicinal Food
2020 Volume.23 No. 3 p.335 ~ p.342
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Efficacy and Safety of Sinetrol-XPur on Weight and Body Fat Reduction in Overweight or Obese Adults: A 12-Week, Randomized, Double-Blind, Parallel, Placebo-Controlled Trial
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Park Seon-Joo
Sharma Anshul
Bae Mun-Hyoung
Sung Ha-Chang
Kim Nam-Ki
Sung Eun-Ju
Lee Hae-Jeung
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Abstract
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This study investigated the effect of Sinetrol-XPur on weight and body fat reduction in overweight or obese Korean participants. Among 100 overweight or obese participants enrolled in a 12-week randomized, double-blinded, controlled study, 86 participants completed the trial. Participants took either two Sinetrol-XPur tablets (450?mg per tablet) or two placebo tablets once a day. Bodyweight, body fat percentage, body mass index (BMI), body fat mass, waist circumference, and various safety parameters were measured. After the 12-week intervention, a significant reduction was observed in the body fat mass (P?=?.030) by dual-energy X-ray absorptiometry (DEXA), body weight (P?=?.002), and BMI (P?=?.002) compared to the placebo. Body fat percentage (P?=?.007) by DEXA showed a significant reduction in the Sinetrol-XPur group, but no difference compared to the control group. Abdominal metabolic risks by computed tomography and blood biochemistry analysis were significantly decreased in the Sinetrol-XPur group, but there were no differences between the Sinetrol-XPur and placebo groups. Safety profiles were not different between the two groups. These results suggested that Sinetrol-XPur significantly reduced body weight, body fat mass, and BMI in obese Korean subjects, which confirms the antiobesity effect of Sinetrol-XPur in the Korean population.
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KEYWORD
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body fat mass, body mass index, bodyweight, obesity, Sinetrol-XPur
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